Antiviral Protection and Therapy of Natural Products

Authors

  • Mirela Ahmadi Faculty of Bioengineering of Animal Resources, University of Agricultural Sciences and Veterinary Medicine of Banat ”King Michael I of Romania”, Calea Aradului No. 119, Timişoara - 300645, Romania;
  • Lavinia Ștef Faculty of Bioengineering of Animal Resources, University of Agricultural Sciences and Veterinary Medicine of Banat ”King Michael I of Romania”, Calea Aradului No. 119, Timişoara - 300645, Romania;
  • Gabi Dumitrescu Faculty of Bioengineering of Animal Resources, University of Agricultural Sciences and Veterinary Medicine of Banat ”King Michael I of Romania”, Calea Aradului No. 119, Timişoara - 300645, Romania;
  • Liliana Ciochina-Petculescu Faculty of Bioengineering of Animal Resources, University of Agricultural Sciences and Veterinary Medicine of Banat ”King Michael I of Romania”, Calea Aradului No. 119, Timişoara - 300645, Romania;
  • Marioara Nicula Faculty of Bioengineering of Animal Resources, University of Agricultural Sciences and Veterinary Medicine of Banat ”King Michael I of Romania”, Calea Aradului No. 119, Timişoara - 300645, Romania;
  • Florica Emilia Morariu Faculty of Bioengineering of Animal Resources, University of Agricultural Sciences and Veterinary Medicine of Banat ”King Michael I of Romania”, Calea Aradului No. 119, Timişoara - 300645, Romania;
  • Dorel Dronca Faculty of Bioengineering of Animal Resources, University of Agricultural Sciences and Veterinary Medicine of Banat ”King Michael I of Romania”, Calea Aradului No. 119, Timişoara - 300645, Romania;
  • Marius Laurian Maftei Faculty of Animal Productions Engineering and Management, University of Agricultural Sciences and Veterinary Medicine of Bucharest, 59 Marasti Boulevard, District 1, Bucharest – 011464, Romania
  • Ioan Peț Faculty of Bioengineering of Animal Resources, University of Agricultural Sciences and Veterinary Medicine of Banat ”King Michael I of Romania”, Calea Aradului No. 119, Timişoara - 300645, Romania;

Keywords:

viruses, natural products, viral diseases

Abstract

In latest years, researchers have been concerned about the resistance, recurrence, and dormancy of viruses that occurs
in the prevention and treatment of viruses. Regarding the current pandemic conditions reported not only to the SARSCoV-2 virus (2019), but also to the SARS-CoV-1 virus (Severe Acute Respiratory Syndrome Coronavirus from 2013)
and MERS-CoV (Middle East Respiratory Syndrome Coronavirus from 2018), it is mentioned that there are scientific
publications that demonstrate the benefits of treatments with natural products. Some natural products rich in
phytonutrients can be used as an alternative to the prevention and treatment of viral diseases along with some treatments
with pharmaceuticals that are very good, but are more aggressive towards the body. Some of the natural products – to
be more effective – are used in processed form – as essential oils, as products obtained by distillation under specific
conditions, as tinctures or as aqueous or alcoholic extracts – these being tested by in vivo and in vitro experiments.
Asia is one of the continent with a tradition in natural herbal treatments, and the origin of these pandemic viruses has
further driven researchers to seek and develop new techniques and methods to obtain natural products – concentrated
enough to be effective but not no harm to patients. Also, the World Health Organization promotes innovations
regarding new potential treatments for new viral diseases and also welcomes traditional, alternative, and
complementary medicine – which can have an important role in healthcare. And because some of the viral diseases are
found also in animals and humans – the researchers have a very complicated job to find therapies that not only treat
and prevent but also are efficient and safe!

References

D. Paraskevis, E.G. Kostaki, G. Magiorkinis, G.

Panayiotakopoulos, G. Souvinos, S. Tsiodras, Infect.

Genet. Evol., 79 (2020) 104212.

M.N.Boukhatem, W.N. Setzer, J. Plants, 800 (2020) 9.

Y. Zhou, Y. Hou, J. Shen, Y. Huang, W. Martin, F.

Cheng, Cell. Discov., 6 (2020) 1-18.

Z. Chen, T. Nakamura, Phytother. Res., 18 (2004) 592-

F.R. Chang, C.T. Yen, M. El-Shazly, W.H. Lin, M.H.

Yen, K.H.Lin, Y.C. Wu, Natural Product

Communications, 7(11) (2012) 1415-1417.

G. Hoever, L. Baltina, M. Michaelis, R. Kondratenko, L.

Baltina, G.A. Tolstikov, H.W. Doerr, J. Cinatl, J. Med.

Chem., 48 (2005) 1256-1259.

C. Bailly, G. Vergoten, Pharmacol. Ther., 214 (2020)

V. Sharma, A. Katiyar, R.C. Agrawal (Eds.), Chapter 4:

Glycyrrhiza glabra: Chemistry and Pharmacological

Activity, pp. 87-100, in Sweeteners – J.M. Merillon, K.G.

Ramawat (Editors), Springer International Publishing, AG

C-W. Lin, F-J. Tsai, C-H. Tsai, C-C. Lai, L. Wan, T-Y.

Ho, C-C Hsieh, P-D Lee Chao, Antiviral Res., 68 (2005)

-42.

S-h. Li, C. Chen, H-q. Zhang, H-y. Guo, H. Wang, L.

Wang, X. Zhang, S-n. Hua, J. Yu, P-g. Xiao, R-s. Li, X.

Tan, Antiviral Res., 67 (2005) 18-23.

World Health Organization, Regional Office for

Africa, WHO supports scientifically proven traditional

medicine, 04 May 2020.

S. Robertson – Extracts of medicinal plant Artemisia

annua interferes with replication of SARS-CoV-2 in vitro,

News Medical Life Sciences, https://www.newsmedical.net/news/20210111/Extract-of-medicinal-plantArtemisia-annua-interferes-with-replication-of-SARSCoV-2-in-vitro.aspx

M.S. Nair, Y. Huang, D.A. Fidock, S.J. Polyak, J.

Wagoner, M.J. Towler, P.J. Weathers – Artemisia annua

L. extracts inhibit the in vitro replication of SARS-CoV-2

and two of its variants, J. Ethnopharmacology,

doi.org/10.1101/2021.01.08.425825

C-Y. Wu, J-T. Jan, S.H. Ma, C.J. Kuo, H-F. Juan, Y-S.

E. Cheng, H-H. Hsu, H-C. Huang, D. Wu, A. Brik, F-S.

Liang, R-S. Liu, J-M. Fang, S-T. Chen, P-H. Liang, C-H.

Wong, PNAS, 101 (2004) 10012-10017.

S. Huang, L. Liu, Y. Zhang, R. Zhang, C. Zhu, L.

Fan, G. Pei, B. Zhang, Y. Shi, Signal Transduction

and Targeted Therapy, 5 (2020) 266.

J. Shang, Y. Wan, C. Luo, G. Ye, Q. Geng, A.

Auerbach, F. Li, Proc. Natl. Acad. Sci, 117 (2020), 11727-

C. Wang, S. Wang, D. Li, D.Q. Wei, J. Zhao, J. Wang,

Gastroenterology, 159 (2020) 1145-1147

M. Gur, E. Taka, S.Z. Yilmaz, C. Kilinc, U. Aktas, M.

Golcuk, J. Chem. Phys., 153(2020) 75101.

Downloads

Published

2023-09-05