Quality of the Effect of Chelated Chromium on Selected Serum/Plasma Metabolites in Dairy Cattle
Keywords:
chelated chromium, dairy cattle, meta-analysis, plasma/serum metabolites, transition periodAbstract
The impact of supplementing chelated chromium (Cr) in transition cows has increased recently. The objective of this
study was to conduct a systematic review of randomized controlled trials to evaluate the effectiveness of
supplementation of chelated chromium (Cr) on plasma glucose, non-esterified fatty acid (NEFA) and insulin during
the transition period in dairy cows. A total of 322 transition dairy cows, belonged to seven studies from five papers,
were used. The complete steps of meta-analysis were performed according to the standard pathway of PRISMA. For
this reason, a comprehensive meta-analysis was used to accomplish this mission. The effect model and I2 statistic was
used to estimate the degree of heterogeneity. Forest plot was used to present a graphic means and their confidence
intervals, and a heterogeneous degree was explored with meta-regression, also Beggꞌs test was conducted to investigate
the publication bias. Estimated the effect size of chelated Cr on glucose, NEFA, and insulin outcomes during the threetime points (i.e. before, at, after calving) was no significant (glucose ES=(0.049-0.078) 0.015, p-value=0.649; NEFA
ES=(-0.719-0.45) -0.134, p-value=0.653; and insulin ES=(-0.090-0.154) 0.032, p-value=0.611. The heterogeneity was
not significant for all variables (glucose I2=0, p-value=0.981; NEFA I2=0 p-value=1; and insulin I2=0, pvalue=0.980). Consequently, fixed-effects models were used for the analysis of such data. Furthermore, Beggꞌs test
indicated no evidence of substantial publication bias for all parameters. The influence analysis showed that the removal
of any study did not change the direction or significance of point estimates. The meta-analysis of our study indicated
that chelated Cr supplementation of diets of dairy cows during the transition period provided a glucose tolerance effect
by increasing the insulin response and decrease NEFA concentration, but not in a significant level.
References
Mirzaei, M., Ghorbani, G. R., Khorvash, M.,
Rahmani, H. R., Nikkhah, A., Chromium improves
production and alters metabolism of early lactation cows
in summer, Journal of Animal Physiology and Animal
Nutrition, 2011, 95, 81-9.
Yasui, T., McArt, J. A. A., Ryan, C. M., Gilbert, R.
O., Nydam, D. V., Valdez, F., et al., Effects of chromium
propionate supplementation during the periparturient
period and early lactation on metabolism, performance,
and cytological endometritis in dairy cows, Journal of
Dairy Science, 2014, 97, 6400-10.
Kafilzadeh, F., Shabankareh, H. K., Targhibi, M. R.,
Effect of Chromium Supplementation on Productive and
Reproductive Performances and Some Metabolic
Parameters in Late Gestation and Early Lactation of
Dairy Cows, Biological Trace Element Research, 2012,
, 42-9.
Vincent, J. B., Recent advances in the nutritional
biochemistry of trivalent chromium, Proceedings of the
Nutrition Society, 2007, 63, 41-7.
Al-Saiady, M. Y., Al-Shaikh, M. A., Al-Mufarrej, S.
I., Al-Showeimi, T. A., Mogawer, H. H., Dirrar, A.,
Effect of chelated chromium supplementation on
lactation performance and blood parameters of Holstein
cows under heat stress, Animal Feed Science and
Technology, 2004, 117, 223-33.
Bhanderi, B., Garg, M., Goswami, A., Tandon, M.,
Shankhpal, S., Chromium-a new essential trace mineral
for dairy animals: A review, Livest Res Int., 2016, 4, 94-
Hayirli, A., Bremmer, D. R., Bertics, S. J., Socha, M.
T., Grummer, R. R., Effect of Chromium
Supplementation on Production and Metabolic
Parameters in Periparturient Dairy Cows, Journal of
Dairy Science, 2001, 84, 1218-30.
Spears, J. W., Weiss, W. P., Role of antioxidants and
trace elements in health and immunity of transition dairy
cows, The Veterinary Journal, 2008, 176, 70-6.
Babaei, M., Adibi, M., Ghorbani, G., Effect of
chromiummethionine supplementation on plasma
NEFA, BHB and insulin concentrations in Holstein
dairy cows during transitional period, 4th Int Conf Agric
Anim Sci Singapore, 2012, 22-4.
Sadri, H., Ghorbani, G. R., Rahmani, H. R., Samie,
A. H., Khorvash, M., Bruckmaier, R. M., Chromium
supplementation and substitution of barley grain with
corn: Effects on performance and lactation in periparturient dairy cows, Journal of Dairy Science,
, 92, 5411-8.
Israel, H., Richter, R. R., A guide to understanding
meta-analysis, J Orthop Sports Phys Ther., 2011, 41,
-504.
Haidich, A. B., Meta-analysis in medical research,
Hippokratia, 2010, 14, 29-37.
Higgins, J. P. .T, Thompson, S. G., Deeks, J. J.,
Altman, D. G., Measuring inconsistency in metaanalyses, B. M. J., 2003, 327, 557-60.
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G.,
Preferred reporting items for systematic reviews and
meta-analyses: the PRISMA statement, Ann Intern
Med., 2009, 151, 264-9.
Duffield, T. F., Rabiee, A. R., Lean, I. J., A MetaAnalysis of the Impact of Monensin in Lactating Dairy
Cattle. Part 1. Metabolic Effects, Journal of Dairy
Science, 2008, 91, 1334-46.
Chen, B., Wang, C., Wang, Y. M., Liu, J. X., Effect
of biotin on milk performance of dairy cattle: A metaanalysis1, Journal of Dairy Science, 2011, 94, 3537-46.
Begg, C. B., Mazumdar, M., Operating
Characteristics of a Rank Correlation Test for
Publication Bias, Biometrics, 1994, 50, 1088-101.
Duffield, T., Rabiee, A., Lean, I., A meta-analysis of
the impact of monensin in lactating dairy cattle. Part 1.
Metabolic effects, Journal of Dairy Science, 2008, 91,
-46.
St-Pierre, N. R., Invited Review: Integrating
Quantitative Findings from Multiple Studies Using
Mixed Model Methodology, Journal of Dairy Science,
, 84, 741-55.
Tomlinson, D., Socha, M., DeFrain, J., Role of trace
minerals in the immune system. Proc Penn State Dairy
Cattle Nutrition Workshop Grantville, PA2008, pp. 39-
Khalili, M., Foroozandeh, A., Toghyani, M.,
Lactation performance and serum biochemistry of dairy
cows fed supplemental chromium in the transition
period, African Journal of Biotechnology, 2011, 10,
-10.
Bin-Jumah, M., Abd El-Hack, M. E., Abdelnour, S.
A., Hendy, Y. A., Ghanem, H. A., Alsafy, S. A., et al.,
Potential use of chromium to combat thermal stress in
animals: A review, Science of The Total Environment,
, 707, 135996.
Spears, J. W., Whisnant, C. S., Huntington, G. B.,
Lloyd, K. E., Fry, R. S., Krafka, K., et al., Chromium
propionate enhances insulin sensitivity in growing
cattle, Journal of Dairy Science, 2012, 95, 2037-45.
Leiva, T., Cooke, R., Brandão, A., Aboin, A.,
Ranches, J., Vasconcelos, J., Effects of excessive energy
intake and supplementation with chromium propionate
on insulin resistance parameters, milk production, and
reproductive outcomes of lactating dairy cows,
Livestock Science, 2015, 180, 121-8.
Balan, I. M., Popescu, A. C., Iancu, T., Popescu, G.,
Tulcan, C., Food safety versus food security in a world
of famine Journal of Advanced Research in Social
Sciences and Humanities, 2020, 5(1), 20-30
Savici, J., Boldura, O. M., Balta, C., Brezovan, D.,
Muselin, F., Mircu, C., Borza, C., Motoc, M., Tulcan,
C., Protective Effect of Hypericum perforatum L.
Extract on Hexavalent Chromium Induced Toxicity in
Rat Adrenal Gland, Revista de Chimie (Rev. Chim.),
, 68(9), 2014-2017.
