Effect of a Diet Contaminated with Ochratoxin A at the Highest Level Allowed by Eu on the Inflammation and the Oxidative Stress in the Spleen of Weaned Piglets
Keywords:
EU regulation, ochratoxin, spleen, weaned pigletsAbstract
Ochratoxins are fungal secondary metabolites produced during storage by fungus of the genera Aspergillus, mainly in tropical and warmer regions and by Penicillium verrucosum, in temperate and colder areas. The most commonly occurring and most toxic member is ochratoxin A (OTA). OTA has multiple toxicity, being nephrotoxic, genotoxic and immunotoxic. According to the Commission Recommendation no. 576/2006 concerning the presence of OTA in products intended for animal feeding, the maximum level admitted for OTA in complementary and complete feeding stuffs for pigs is 0.05ppm. However, these guidance values are only a recommendation, and the establishment of a legal regulation needs additional toxicological data issued from farm animal experiments. The aim of the present paper was to investigate the effect of the EU recommended OTA maximal tolerable feed concentration (0.05 mg/kg) on the spleen of weaned pigs.
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