EFFECT OF A SYNTHESIS PRODUCT (BY-PRODUCT OF SALICYLIC ACID) IN COMPARISON WITH BASIS STRUCTURAL COMPOUNDS ON SOME PROTEIC METABOLISM PARAMETERS IN RATS
Keywords:
protein, albumin, urea, creatinine, ratAbstract
The aim of the study was to relieve the effect of synthesis product (by-product of
salicylic acid) administration 5-cloro-2hidroxy-azotil-sulfamoil-fenil benzamide
(5ClSA-SA) in comparison with basic structural compounds (salicylamide and
sulfanilamide) on some parameters of proteic metabolism on rats. The synthesis
product 5ClSA-SA is amide of 5 chlorosalycilic acid with sulfanilamide synthesized
at The Technical University, Faculty of Industrial Chemistry of Timisoara. The
experimental results demonstrate that the synthesis product has determinate a strong
significant increase (p<0.01) of proteinemia compared to test, over the physiological
limits; salicylamide has induces the significant increase (p<0.05), and sulfanilamide
has induced the significant decrease (p<0.05) of total proteins compared to test but
in physiological limits. After the administration of the three substances, the albumin
and urea values has strong significant decrease (p<0.01) compared to test and under
the physiological limits. The synthesis product has not determinate significant
differences (p>0.05) of creatinine compared to test, obtained values being situated in
physiological limits, while salicylamide and sulfanilamide have induced strong
significant decrease (p>0.01), respectively significant (p>0.05) compared to test and
under physiological limits.
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