THE IMPACT OF IN VIVO ADMINISTRATION OF A SYNTHESIS PRODUCT (BY-PRODUCT OF SALICYLIC ACID) ON SOME BIOCHEMICAL PARAMETERS ON RATS
Keywords:
glycemia, cholesterol, triglyceride, ratAbstract
The goal of this study is to establish the in vivo impact of a by-product of salicylic
acid, 5-cloro-2-hidroxy-azotyl-sulfamoil-phenyl benzamyde synthesis product
(5ClSA-SA), synthesized at the Technical University, Faculty of Industrial Chemistry
of Timisoara, on some parameters of energetic metabolism. The experimental results
shows that the synthesis product has induced a strong significant increase (p<0.01)
of glycemia compared to tests, in direct relation with administration period and a
fluctuation of cholesterol values with decrease followed by strong significant
increase (p<0.01) compared to tests. Glycemia and plasmatic cholesterol values
were situated between physiological limits. Triglycerides registered strong
significant increases (p<0.01) in direct relation with administration period, over the
physiological limits.
References
Chişu I. (1994) – Glucides and glicoproteines metabolism. Ed. Mirton,
Timişoara,.
Dejica D.(2000) – Oxidatice stress in internal diseases, Ed. Casa CărŃii de
ştiinŃă, Cluj-Napoca.
Gilbert.A.L., Chakrabarty K.(2008).- Total lipid and cholesterol levels
in plasma and liver of rats fed diets supplemented with sulfaguanine or
succinylsulfathiazole- Jn.Nutrition. org.,95,88-94.
Kamisako, T.,Y.Aachi,Y.Yamatoko (1990)- Effect of UDP-glucuronic
acid depletion by salicylamide on biliary bilirubin excretion in the rat, J.
Pharmacol. Exp. Ther., 254: 380-382.
Lupea, A.X., M., Pădure, (2003) - Synthesis and characterization of some
N-substituted Amides in Salicylic Acid Series, Rewiew of Research, Faculty of
Sciences, Univ. of Novi Sad, 104, 5-10.
Lupea,A.X., M.,Pădure, C.Tărăbăşanu, (2003) Synthesis and
characterization of some N-substituted amides in 5-Chlorosalycilic Acid Series,
Revista Chimie (Bucureşti) 54 (9) 752-756.
Meingassner G., F.P Schmook. (1992) – Reference values for Crl:CD
(SD)BR Rats –Sandoz-Research Institute, Viena,.
Pădure, M. (2003) - Studii pentru obŃinerea de noi derivaŃi ai acidului
salicilic cu aplicaŃii în industria organică de sinteză fină, Timişoara, teza doctorat.
Stana, L. (2007) -The effect of a new salicylic acid synthesis compounds
administration on serum transaminasis, Lucr. St. Zootehnie şi Biotehnologii,
(1),188-194.
Wilard D.M., Tveden H., Turnal H.G. (1989) - Small clinical diagnosis
By Laboratory methods , W.B.Saunders Company, Viena,
Zamfirescu-Gheorghiu, M., A., Popescu (1991)- Tratat de Biochimie
medicală Ed. Med. Bucureşti.
www.ivis.org/advances/Beasley/Cpt4/chapter_frm.asp?LA=1#Aspiri
na.
