THE IMPACT OF IN VIVO ADMINISTRATION OF A SYNTHESIS PRODUCT (BY-PRODUCT OF SALICYLIC ACID) ON SOME BIOCHEMICAL PARAMETERS ON RATS

Authors

  • LETITIA STANA Faculty of Veterinary Medicine, Timisoara, Romania
  • ALEXANDRA TRIF Faculty of Veterinary Medicine, Timisoara, Romania
  • F. MUSELIN Faculty of Veterinary Medicine, Timisoara, Romania
  • ALFA XENIA LUPEA Industrial Chemistry and Environmental Engineering Faculty, Timisoara, Romania
  • MIRABELA PADURE Industrial Chemistry and Environmental Engineering Faculty, Timisoara, Romania

Keywords:

glycemia, cholesterol, triglyceride, rat

Abstract

The goal of this study is to establish the in vivo impact of a by-product of salicylic
acid, 5-cloro-2-hidroxy-azotyl-sulfamoil-phenyl benzamyde synthesis product
(5ClSA-SA), synthesized at the Technical University, Faculty of Industrial Chemistry
of Timisoara, on some parameters of energetic metabolism. The experimental results
shows that the synthesis product has induced a strong significant increase (p<0.01)
of glycemia compared to tests, in direct relation with administration period and a
fluctuation of cholesterol values with decrease followed by strong significant
increase (p<0.01) compared to tests. Glycemia and plasmatic cholesterol values
were situated between physiological limits. Triglycerides registered strong
significant increases (p<0.01) in direct relation with administration period, over the
physiological limits.

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Published

2023-11-01