STRUCTURAL CHANGES IN THE RAT TESTES CAUSED BY DIAZINON ADMINISTRATION

R. TOMAN, S. HLUCHÝ, B. ŠIŠKA, M. CABAJ, J. GOLIAN, P. MASSÁNYI, N. LUKÁČ

Abstract


The aim of this study was to find the structural changes in the rat testis after a diazinon administration. The testis structure changes after the diazinon administration of 20 mg/kg b.w. (i.p.) and daily dose of 40 mg/l in drinking water (p.o.) were evaluated in light microscopy. 36 hours after the diazion i.p. administration, the vacuolization of the seminiferous epithelium, evacuation of germ cells into the tubule lumen, epithelium necrosis and interstitium extension were observed. After 90 days of daily oral administration, the changes in the testis were not as visible as in the acute intoxication. The germ cells released from the basal lamina and then were visible in the tubule lumen. Diazinon causes the damage of the germinal epithelium in the testes leading to the spermatogenesis failure. The infertility can then appear.


Keywords


diazinon; testis; histology; morphometry; rat

Full Text:

PDF

Refbacks

  • There are currently no refbacks.


Copyright (c)


Scientific Papers Animal Science and Biotechnologies publish open access articles under the terms of the Creative Commons Attribution 4.0 Licence (read full legal code).


LUCRARI STIINTIFICE ZOOTEHNIE SI BIOTEHNOLOGII (SCIENTIFIC PAPERS ANIMAL SCIENCE AND BIOTECHNOLOGIES)

ISSN print 1841 - 9364
ISSN online 2344 - 4576
ISSN-L  1841 - 9364
(former ISSN 1221-5287, E-ISSN 1841-9364)

PUBLISHER: AGROPRINT Timisoara, Romania
PAPER ACCESS: Full text articles available for free
FREQUENCY: Semiannual
PUBLICATION LANGUAGE: English
_________________________________________________________________

Banat´s University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara
Faculty of Animal Science and Biotechnologies
300645, Timişoara, Calea Aradului 119, Romania

E-mail: spasb [at] animalsci-tm.ro
Phone: +40-256-277160, Fax.: +40-256-277110