Potassium Dichromate Impact on Male Reproductive Integrity Biomarker in Rat. Two Generation Study

Jelena Rankov, Alexandra Trif, Diana Brezovan, Florin Muselin

Abstract


The aim of this study was the evaluation of Cr VI cumulative and differentiate exposure on integrity biomarker of male reproductive system. The objective was evaluation of potassium dichromate intake on genital organs and sexual accessory glands architecture in male rats from two generation. Males and females from F0 generation were exposed to potassium dichromate three months before mating. F1 generation was represented by male pups, resulted from F0 generation, exposed to potassium dichromate in utero, during suckling (via milk and water) period and until sexual maturity. All the animals were divided in one control and three experimental groups, exposed to Cr VI trough drinking water, as followed E1: 25 ppm (LOAEL); E2: 50 ppm: E3: 75 ppm; control group received tap water without chromium content. The experiment was carried out with respecting legislation regarding ethics in animal experiments. The study revealed the presence of congestive and degenerative lesions in genital organs and sexual accessory glands of exposed individuals from F0 and F1 generation such as: interstitial edema, epithelial necrosis and atrophy, membrane exfoliation and necrosis. The lesions frequency and intensity were directly correlated to exposure level, the most affected being E3 group and generation, more pronounced in F1 generation.


Keywords


chromium VI; histoarchitecture; male; rat; toxicity

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Scientific Papers Animal Science and Biotechnologies publish open access articles under the terms of the Creative Commons Attribution 4.0 Licence (read full legal code).


LUCRARI STIINTIFICE ZOOTEHNIE SI BIOTEHNOLOGII (SCIENTIFIC PAPERS ANIMAL SCIENCE AND BIOTECHNOLOGIES)

ISSN print 1841 - 9364
ISSN online 2344 - 4576
ISSN-L  1841 - 9364
(former ISSN 1221-5287, E-ISSN 1841-9364)

PUBLISHER: AGROPRINT Timisoara, Romania
PAPER ACCESS: Full text articles available for free
FREQUENCY: Semiannual
PUBLICATION LANGUAGE: English
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Banat´s University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara
Faculty of Animal Science and Biotechnologies
300645, Timişoara, Calea Aradului 119, Romania

E-mail: spasb [at] animalsci-tm.ro
Phone: +40-256-277160, Fax.: +40-256-277110