The Use of Yellow Dock (Rumex crispus L.) and Goji Berry (Lycium barbarum L.) in Alloxan Induced Diabetes Mellitus in Rats

Florin Muselin, Diana Brezovan, Jelena Savici, Romeo T. Cristina, Eugenia Dumitrescu, Alexandru O. Doma, Doru Morar, Alexandra Trif


The present study emphasize the effect of R. crispus and L. barbarum 6% aqueous extract on blood sugar level in Alloxan induced diabetes in rats. The rats were divided in five groups: one non-diabetic control and four experimental groups with induced diabetes mellitus after 40 mg/kg b.w. intravenous administration of 2% Alloxan. One group was kept as diabetic control and in the other three groups was administered 6% aqueous extracts of R. crispus, L. barbarum or a combination of the extracts during seven weeks. The better results were obtained in case of L. barbatum (goji) extract administration followed by the R. crispus (yellow dock) extract. The combination of the two extracts proven to have a weaker effect than the extracts given separately.


Alloxan; dock; diabetes; goji, rats

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Ahmed, M.F., Kazim, S.M., Ghori, S.S., Mehjabeen, S.S., Ahmed, S.R., Ali, S.M., Ibrahim, M., Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats, International Journal of Endocrinology, Volume 2010, doi:10.1155/2010/841090

Alupului, A., Calinescu, I., Lavric, V., Ultrasonic vs. microwave extraction intensification of active principles from medicinal plants, AIDIC Conference Series, 2009, 09, 1-8, doi:10.3303/ACOS0909001

Ankur, R., Shahjad, A., Alloxan Induced Diabetes: Mechanisms and Effects, International Journal of Research in Pharmaceutical and Biomedical Sciences, 2012, 3, 2, 819-823

Carvalho, E.N., Carvalho, N.A.S., Ferreira, L.M., Experimental model of induction of diabetes mellitus in rats, Acta Cir Bras [serial online] Vol.1 8 Special Edition, 2003. Home page address:

Das, J., Vasan, V., Sil, P.C., Taurine exerts hypoglycemic effect in alloxan-induced diabetic rats, improves insulin- mediated glucose transport signaling pathway in heart and ameliorates cardiac oxidative stress and apoptosis, Toxicol Appl Pharmacol, 2012, 258, 296-308

Etuk, E.U., Animals models for studying diabetes mellitus, Agric Biol J N Am, 2010, 1, 130 - 134

Jimoh, F.O., Adedapo, A.A., Aliero, A.A., Afolayan, A.J., Polyphenolic contents and biological activities of Rumex ecklonianus, Pharmaceutical Biology, 2008, 46, 333–340

Kumar, S.D., Surajit, K.G., Sorra, S., Joyeeta, T., Dipankar, S., Assessment of In vitro Antioxidant potential and In vivo Anti-diabetic Activity on Streptozotocin-induced Diabetic Rats of Rumex maritimusL., Asian Journal of Biochemical and Pharmaceutical Research, 2014, 4, 2, 164-170

Kruger, D.F., Lorenzi, G.M., Dokken, B.B., Sadler, C.E., Mann, K., Valentine, V., Managing diabetes with integrated teams: maximizing your efforts with limited time, Postgrad Med, 2012, 124, 64-76

Maksimović, Z., Kovačević, N., Lakušić, B., Ćebović, T., Antioxidant activity of yellow dock (Rumex crispus L., Polygonaceae) fruit extract, Phytother. Res., 2011, 25, 101–105

Poterat, O., Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity, Planta Med., 2010, 76, 7–19

Smolarz, H.D., Wegiera, M., Matyjasik, J., Fatty acids composition in fruits of Rumex L. genus. Annales UMCS Sectio DDD, 2008, 21, 133–137

Song, Y., Xu, B., Diffusion profiles of health beneficial components from Goji berry (Lyceum barbarum) marinated in alcohol and their antioxidant capacities as affected by alcohol concentration and steeping time, Foods, 2013, 2, 32-42

Srinivasan, K., Ramarao, P., Animal models in type 2 diabetes research: an overview, Ind J Med Res, 2007, 125, 451-72

Wegiera, M., Grabarczyk, P., Baraniak, B., Smolarz, H., Antiradical properties of extracts from roots, leaves and fruits of six Rumex L. species, Acta Biologica Cracoviensia Series Botanica, 2011, 53, 1, 125–131


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