EFFECT OF A SYNTHESIS PRODUCT (BY-PRODUCT OF SALICYLIC ACID) IN COMPARISON WITH BASIS STRUCTURAL COMPOUNDS ON SOME PROTEIC METABOLISM PARAMETERS IN RATS

LETIłIA STANA, ALEXANDRA TRIF, LOREDANA GABRIELA STANA, ALFA XENIA LUPEA, MIRABELA PĂDURE, F. MUSELIN

Abstract


The aim of the study was to relieve the effect of synthesis product (by-product of salicylic acid) administration 5-cloro-2hidroxy-azotil-sulfamoil-fenil benzamide (5ClSA-SA) in comparison with basic structural compounds (salicylamide and sulfanilamide) on some parameters of proteic metabolism on rats. The synthesis product 5ClSA-SA is amide of 5 chlorosalycilic acid with sulfanilamide synthesized at The Technical University, Faculty of Industrial Chemistry of Timisoara. The experimental results demonstrate that the synthesis product has determinate a strong significant increase (p<0.01) of proteinemia compared to test, over the physiological limits; salicylamide has induces the significant increase (p<0.05), and sulfanilamide has induced the significant decrease (p<0.05) of total proteins compared to test but in physiological limits. After the administration of the three substances, the albumin and urea values has strong significant decrease (p<0.01) compared to test and under the physiological limits. The synthesis product has not determinate significant differences (p>0.05) of creatinine compared to test, obtained values being situated in physiological limits, while salicylamide and sulfanilamide have induced strong significant decrease (p>0.01), respectively significant (p>0.05) compared to test and under physiological limits.


Keywords


protein; albumin; urea; creatinine; rat

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LUCRARI STIINTIFICE ZOOTEHNIE SI BIOTEHNOLOGII (SCIENTIFIC PAPERS ANIMAL SCIENCE AND BIOTECHNOLOGIES)

ISSN print 1841 - 9364
ISSN online 2344 - 4576
ISSN-L  1841 - 9364
(former ISSN 1221-5287, E-ISSN 1841-9364)

PUBLISHER: AGROPRINT Timisoara, Romania
PAPER ACCESS: Full text articles available for free
FREQUENCY: Semiannual
PUBLICATION LANGUAGE: English
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Banat´s University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara
Faculty of Animal Science and Biotechnologies
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