INCIDENCE OF JUNCTIONAL EPIDERMOLYSIS BULLOSA AMONG ROMANIAN DRAFT HORSES

S.E. GEORGESCU, MARIA ADINA MANEA, STELIANA KEVORKIAN, MIHAELA ZAULET, MARIETA COSTACHE

Abstract


Junctional Epidermolysis Bullosa (JEB) is an inherited disease which causes skin lesions in newborn foals and results in large areas of skin loss. The mutation responsible for the disease is a cytosine insertion in the LAMC2 gene, which results in absent expression of the laminin γ2 polypeptide chain of laminin 5. JEB is inherited as an autosomal recessive trait (Spirito et al. 2002, Milenkovic et al. 2003). Our objective was to analyze Romanian Draft Horses using a set of primers which amplify a fragment from the LAMC2 gene possibly containing the insertion for correctly identifying the normal homozygous and heterozygous carrier horses for the JEB trait. The number of allele peaks depends on whether the horse tested is a heterozygote (carrier) or homozygote (normal or JEB affected). Results suggest that the genetic test will be useful in identifying horses which are heterozygous for the JEB trait and foals with JEB.


Keywords


Romanian Draft Horse; JEB; carrier; diagnostication

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LUCRARI STIINTIFICE ZOOTEHNIE SI BIOTEHNOLOGII (SCIENTIFIC PAPERS ANIMAL SCIENCE AND BIOTECHNOLOGIES)

ISSN print 1841 - 9364
ISSN online 2344 - 4576
ISSN-L  1841 - 9364
(former ISSN 1221-5287, E-ISSN 1841-9364)

PUBLISHER: AGROPRINT Timisoara, Romania
PAPER ACCESS: Full text articles available for free
FREQUENCY: Semiannual
PUBLICATION LANGUAGE: English
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Banat´s University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara
Faculty of Animal Science and Biotechnologies
300645, Timişoara, Calea Aradului 119, Romania

E-mail: spasb [at] animalsci-tm.ro
Phone: +40-256-277160, Fax.: +40-256-277110